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EC number: 940-217-6 | CAS number: -
Table 1 Skin Grades Following Primary Challenge - Test Group
Table 2 Skin Grades Following Primary Challenge - Naïve Control Group
Table 3 Induction Scores of the Test Group
The test material was investigated for dermal sensitisation potential utilising a Buehler guinea pig test in accordance with the standardised guidelines OECD 406 and EPA OPPTS 870.2600. The test was also PR 86-5 compliant.
In the induction phase of the exposure, 0.4 mL of the test material was applied at a 15 % w/w concentration in distilled water to the clipped left shoulder of 20 Hartley guinea pigs. The application was done using a Hilltop Chamber secured in an occlusive fashion for 6 hours. Two additional induction doses were conducted following the same procedure, at weekly intervals.
Two weeks after the final application, the animals received a topical primary challenge dose (6 hour occlusive contact) of the test material at 7.5 % concentration w/w in distilled water on a naive site located on the right shoulder. Animals were scored for irritation at 24 and 48 hours after initiation of the primary challenge application.
Ten guinea pigs served as a naive control group, and remained untreated through the induction phase. Five naive control animals received the primary challenge dose, at a 7.5 % concentration.
The incidence and severity of the responses in the test animals were not significantly greater than those produced by the naive control group, indicating that sensitisation had not been induced.
Under the conditions of this study, it was determined that the test material did not induce sensitisation in accordance with EU criteria.
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