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Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
January-December 1986
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report date:
1988

Materials and methods

Principles of method if other than guideline:
Aqueous and methanol solutions of iodixanol were prepared and stored in 2 ml volumetric flasks with a plastic stopper. The bottles were inspected visually during 10 months.
GLP compliance:
not specified
Type of method:
flask method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Water solubility
Water solubility:
> 1 other: g/mL
Temp.:
4 °C
pH:
> 5 - < 7

Any other information on results incl. tables

The solubility of iodixanol in water is more than 1g/ml at 4oC and at room temperature. The experiment was performed January-December 1986.

Performance: Solution of iodixanol was prepared in 2ml volumetric flsk with a plastic stopper. The bottles were inspected visually during 10 months. Concentration, storage conditions and results are given in Table 1.

Solvent

Concentration w/v %

Temperature

oC

Visual inspection

Water

60

4

Clear solution

Water

70

4

Clear solution

Water

100

4

Clear solution

Water

100

RT

Clear solution

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): soluble (1000-10000 mg/L)