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Donepezil was not mutagenic in the Ames reverse mutation assay in bacteria, or in a mouse lymphoma forward mutation assay in vitro. In the chromosome aberration test in cultures of Chinese hamster lung (CHL) cells, some clastogenic effects were observed. Donepezil was not clastogenic in the in vivomouse micronucleus test and was not genotoxic in an in vivo unscheduled DNA synthesis assay in rats.

Short description of key information:
Data on the substance Donepezil hydrochloride CAS 120014-06-4

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Justification for classification or non-classification