Registration Dossier
Registration Dossier
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EC number: 201-756-6 | CAS number: 87-60-5
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
For the test substance 3 -chloro-o-toluidine no data on reproduction toxicity are available.
Data from structurally similar substance 5 -chloro-o-toluidine (CAS 95 -79 -4) is available. However, since only limited information for these data are available, they are considered insufficient for a reliable evaluation of the reproduction toxicity potential of 3 -chloro-o-toluidine, and thus, for classification purpose. Nevertheless, these data will be presented shortly below.
CAS 95 -79 -4: 5 -chloro-o-toluidine was applied intraperitoneally to groups of 5 male mice daily on five consecutive days (Topham, 1980). The substance was diluted in corn oil and was applied at following doses: 50, 100, 250, and 500 mg/kg bw/day. The highest dose was found to be lethal. In the remaining dose groups, five weeks after last application the sperms were analyzed with the focus on abnorm sperm heads. 5 -choro-o-toluidin did not induce a higher number of abnormal sperms.
Short description of key information:
No data are available for 3-chloro-o-toluidine.
Data from structurally similar substance 5 -chloro-o-toluidine (CAS 95 -79 -4) is available. However, since only limited information for these data are available, they are considered insufficient for a reliable evaluation of the reproduction toxicity potential of 3 -chloro-o-toluidine, and thus, for classification purpose.
Justification for classification or non-classification
The available data are not reliable for the evaluation of the toxicity to reproduction.
Additional information
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