Registration Dossier
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EC number: 700-589-0 | CAS number: 1369492-52-3
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The test substance is with high probability acutely not harmful to aquatic invertebrates. No toxic effects occur within the range of water solubility.
Key value for chemical safety assessment
Additional information
Acute toxicity of the mixture to aquatic organisms is derived from ecotoxicological information about the end-product and the by-product.
One GLP study according to OECD guideline 202 (1984) was performed with the end-product (including the impurity exceeding 1%). No immobility was observed with the daphnia during the study.
Two non-GLP static tests were performed with the by-product, according to DIN 38412 (Teil 11). The LC50 was determined to be higher than 2500 mg/L for both experiments.
Toxicity to daphnia is therefore not expected for the test substance.
Reasons for read-across:
The substance was not tested for short-term toxicity to daphnia. The test substance is a mixture which consists mainly of the end-product (approximately 50%) and a by-product (approximately 30%) as well as of different impurities and isomers of the end-product (one exceeding 1%). Therefore, information about short-term toxicity to daphnia are derived from studies performed with the end-product and the major by-product.
Performance and
observations:
A
GLP-compliant study was performed according to OECD guideline 202 (1984)
with Daphnia magna. A water accommodated fraction from 100 mg/L
of the end-product (including the impurity exceeding 1%) was prepared.
Ten daphnia were exposed to the unfiltered solution. Prior to use, it
was passed through a filter of 5 μm pore size. A concentration of 15
mg/L was determined at the beginning of the study. It decreased to 2.5
mg/L after 48 h of exposure.
No immobility was observed during the study. The EC0 and the EC50 are both higher than 100 mg/L, according to nominal concentrations at the beginning of the study.
Short-term toxicity of the by-product was evaluated with 2 non-GLP studies, according to DIN 38412 (Teil 11), with Daphnia magna.
During the first experiment, the daphnia were exposed to the by-product for a period of 24h and the EC0 was determined to be higher than 2500 mg/L.
During the second experiment, the exposure period was 96h and the EC50 was found to be higher than 2500 mg/L.
Discussion:
The
end-product as well as the by-product are not acutely toxic to daphnia.
Toxic effects to daphnia are therefore not predicted for the test substance.
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