Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
secondary source
Title:
No information
Year:
1983
Bibliographic source:
Annales des Falsifications et de l'Expertise Chimique. Vol. 76(815), Pg. 65,

Materials and methods

Principles of method if other than guideline:
Method not published
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
600 mg/kg bw

Any other information on results incl. tables

Behavioral: altered sleep time (including change in righting eflex)

Gastrointestinal: changes in structure or function of salivary glands

Lungs, thorax or respiration: dyspnea

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
An acute oral toxicity study in mouse on the similar substance "2-nitrobenzaldehyde" reported a DL50 oral value of 600 mg/kg bw.