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EC number: 413-110-2
CAS number: 135861-56-2
Toxicity (Oral): LD 50 = >5000 mg/kg bw (OECD 401; GLP)Toxicity (Dermal): LD 50 = >2000 mg/kg bw (Annex V; GLP)
Acute Toxicty: Oral
Two acute oral toxicity studies in the rat were available. In the
supporting study (Annex V B1, GLP), there were no mortalities and no
treatment-related clinical signs; the LD50 was >5000 mg/kg bw. In the
acute oral toxicity key study (OECD 401/GLP), groups of rats (Albino;
5/sex) were given a single oral dose of Flyadd-3 in corn oil at a dose
of 5000 mg/kg bw.
Oral LD50 Males/Females = >5000 mg/kg bw
No deaths were observed and there were no other treatment-related
effects noted. The LD50 value for the acute oral toxicity endpoint is
Acute Toxicity: Dermal
Two acute dermal toxicity studies in the rat were available. In the
supporting limit test study (OECD 402, GLP) groups of rats (Sprague
Dawley; 5/sex) were dermally exposed (semi-occlusive) to the test
substance in liquid paraffin for 24 hrs at a dose of 2,000 mg/kg bw. No
deaths occurred and no signs of toxicity (systemic or local) were
In the acute dermal toxicity key study (Annex V/GLP), groups of rats
(Sprague Dawley; 5/sex) were dermally exposed (semi-occlusive) to the
test substance (skin was moistened with arachis oil B.P.) for 24 hrs at
a dose of 2,000 mg/kg bw.
Dermal LD50 Males/Females = >2,000 mg/kg bw
No deaths occurred and no signs of toxicity (systemic or local) were
observed. There were no toxicologically significant effects on
bodyweight and no abnormalities were noted at necropsy of animals killed
at the end of the study. The LD50 value for the acute dermal toxicity
endpoint is >2000mg/kg bw.
Based on the available information in the dossier, the substance
Flyadd-3 (CAS No. 135861-56-2) does not need to be classified for acute
toxicity or specific target organ toxicity - single exposure when the
criteria outlined in the CLP Regulation (Annex I of 1272/2008/EC) are
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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