Registration Dossier
Registration Dossier
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EC number: 932-728-8 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Phenol Studies VI: The acute and comparative toxicity of phenol and o-, m-, and p-cresols for experimental animals.
- Author:
- Deichmann, W.M,; Witherup, S.
- Year:
- 1 944
- Bibliographic source:
- J. Pharmacol. Exp. Ther. 80, 233-240
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- post exposure observation period 7 days, no necropsy
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Phenol
- EC Number:
- 203-632-7
- EC Name:
- Phenol
- Cas Number:
- 108-95-2
- Molecular formula:
- C6H6O
- IUPAC Name:
- phenol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: reared in the very same institute where study was conducted
- Diet ad libitum
- Water ad libitum:
ENVIRONMENTAL CONDITIONS: no details
:
Administration / exposure
- Route of administration:
- oral: gavage
- Doses:
- 300-800 mg/kg bw: Different amounts of aqueous solutions/emulsions containing 2, 5, 10 or 20% of phenol were orally administered.
- No. of animals per sex per dose:
- 5-15 (number sof males and females equal in each group)
- Control animals:
- no
- Statistics:
- No data
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 340 mg/kg bw
- Based on:
- test mat.
- Remarks:
- 20% Phenol in solution
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 530 - <= 540 mg/kg bw
- Based on:
- test mat.
- Remarks:
- Phenol 2%, 5%, and 10% in solution
- Mortality:
- All rats died within 3 to 150 minutes.
- Clinical signs:
- other: Twitching across the body (from eyes/eyelids to extremities being last affected); body temperature (irregular, mostly subnormal), pulse and respiration rate increasing, then decxreasing, irregular and weak; pupils finally dilated; salivation, marked dyspn
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- After acute oral application in rats the LD50 of phenol varied between 340 and 540 mg/kg bw.
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