Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 240-383-3 | CAS number: 16291-96-6 An amorphous form of carbon produced by partially burning or oxidizing wood or other organic matter.
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-09-24 to 2010-10-09
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1300 (Acute inhalation toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- No aplica
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Charcoal
- EC Number:
- 240-383-3
- EC Name:
- Charcoal
- Cas Number:
- 16291-96-6
- Molecular formula:
- C
- IUPAC Name:
- Carbón vegetal
- Details on test material:
- Batch no.: 29004
Appearance: charcoal typic
Purity: C-Fix: 80.5%; dose calculation not adjusted to purity
Expiry: December 2030
Storage condition: At room temperature, moisture protected
Safety precautions: Routine hygienic procedures
The test atmosphere was generated from the micronized powder of test item as supplied by the Sponsor. No vehicle was used.
The original test item was micronized by mill (Fritsch, Laborette, Lot. 09.203.381) to around 150 µm. This particle size was used in the test. The actual particle size distribution in the breathing zone was determined by the parameters of the aerosol generation system employed.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CRL (WI) BR of Wistar origin
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- The actual concentration of generated atmosphere was measured gravimetrically at regular intervals (about 50-60 min) during exposure by pulling a volume of 4 L of test atmosphere from the exposure chamber through glass fibre filters Fiberfilm T60A20
- Duration of exposure:
- ca. 4 h
- Concentrations:
- 4.968 mg/L
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 4.97 mg/L air
- Exp. duration:
- 4 h
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Bajo las condiciones experimentales de este estudio, no se produjeron muertes en un grupo de diez ratas expuestas a un ambiente medio alcanzado de 4,97 mg / L durante cuatro horas.
La inhalación aguda mediana de la concentración letal (4-h CL50) de carbón vegetal de ensayo elemento en Wistar Crl: (WI) BR ratas, se considera por lo tanto a ser mayor que 4,97 mg / l.
No hubo mortalidad en los animales de prueba.
En consecuencia, la inhalación aguda mediana de la concentración letal (4-h LC 50) de las ratas de carbón tanto, se consideró que ser mayor que 4,97 mg / l.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
