Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
other: theoretical assessment
Adequacy of study:
key study
Study period:
2013
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: A theoretical assessment, non-GLP, based on the REACH guidance IR CSA, R.7, has been performed.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Principles of method if other than guideline:
Expert statement based on the (physico-chemical) properties of the substance.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Dodecene, hydroformylation products, low-boiling
EC Number:
271-240-3
EC Name:
Dodecene, hydroformylation products, low-boiling
Cas Number:
68526-92-1
Molecular formula:
The substance consists of 46 isomers of unsaturated and branched dodecene structures (see Test Report No. A170002983).
IUPAC Name:
Dodecene, hydroformylation products, low-boiling
Test material form:
other: liquid

Results and discussion

Main ADME results
Type:
absorption
Results:
For risk assessment purposes absorption factors for Oxooil LS13 are derived to be 50% (oral), 100% (inhalation) and 50% (dermal).

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): other: Based on its lipophilic characteristics (log Pow of 7.6-8.3) and its low water solubility (≤ 1.2mg/L at 20 °C), the bioaccumulation potential is expected to be high.
Based on its physical/chemical properties, absorption factors for Oxooil LS13 are derived to be 50% (oral), 100% (inhalation) and 50% (dermal) for risk assessment purposes.
Based on its lipophilic characteristics (log Pow of 7.6-8.3) and its low water solubility (≤ 1.2mg/L at 20 °C), the bioaccumulation potential is expected to be high.