N,N'-(3,3'-dimethylbiphenyl-4,4'-ylene)di(acetoacetamide)

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2013

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: well performed study according to acknowledged rules

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2013

Report date:

2013

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: company SOP

Principles of method if other than guideline:

A laser beam is shone into a cloud of dispersed particles. The diffraction pattern is measured by a series of photodetectors at different angles. Large particles scatter the light mainly in the forward direction, small particles at larger angles. This is described by the Mie theory. With a suitable fit algorithm, the particle size distribution is adjusted so that calculated and observed scattering intensities agree. Particles within a size range of 1 to 1000 µm can be detected.
Laser diffraction particle sizing measured using Mastersizer 2000 (Malvern Instruments Ltd.). Within the Mastersizer 2000 system, consistent and controlled measurements are achieved through the clear specification of sample dispersion units and critical operating parameters, which ensures proper quality control according to ISO 13320 -1.
Standard operating procedure for dispersion of dry pigment is applied. Particle flow controlled using variable feed-rate vibrating tray unit (Scirocco) . Dispersion achieved by accelerating particles with a compressed air stream of 4 bar.
Measuring time: 10 s; 2 measurements within an interval of 5s are performed (averaged for result)
Concentration: 0.0006 %Vol
Dual wavelength measurement (He-Ne-Laser and blue solid state light source)
Evaluation using Fraunhofer approximation.
Given standard deviation is based on the general experience with the method and pigments. The estimated values are typical standard deviations for pigments:
D10: 4% of D10 (minimum value 0,05 µm)
D50: 13% of D50 (minimum value 0,1 µm)
D90: 29% of D90 - D50

GLP compliance:

no

Type of distribution:

volumetric distribution

Test material

Test material information

Constituent 1

Reference substance name:

N,N'-(3,3'-dimethylbiphenyl-4,4'-ylene)di(acetoacetamide)

EC Number:

202-111-1

EC Name:

N,N'-(3,3'-dimethylbiphenyl-4,4'-ylene)di(acetoacetamide)

Cas Number:

91-96-3

Molecular formula:

C22H24N2O4

IUPAC Name:

N,N'-(3,3'-dimethylbiphenyl-4,4'-diyl)bis(3-oxobutanamide)

Details on test material:

Purity: 99.1 %

Results and discussion

Particle size

Particle size 1

Percentile:

D50

Mean:

5.4 µm

Remarks on result:

other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.

Particle size 2

Percentile:

D10

Mean:

1 µm

St. dev.:

0.1

Particle size 3

Percentile:

D50

Mean:

5.4 µm

St. dev.:

0.7

Particle size 4

Percentile:

D90

Mean:

313.4 µm

St. dev.:

89.3

Applicant's summary and conclusion

Conclusions:

The mass median diameter D50 of the substance is 5.4 µm

Executive summary:

The particle size distribution of the substance was determined with a Malvern Mastersizer 2000, unit: Scirocco 2000 apparatus. The mass median diameter was found to be 5.4 µm.