Registration Dossier

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2014
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
no guideline followed
Principles of method if other than guideline:
Determination of the solubility of the test item in octanol and in water separately by spectrometry, to calculate the partition coefficient
GLP compliance:
no
Type of method:
estimation method (solubility ratio)
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
- Lot/batch No.: 407940
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
ca. 3.9
Temp.:
22 °C
pH:
< 8
Remarks on result:
other: pH not mentionned in the study

Concentration of the test item in octanol extract:

Weight of test item added

35.5 g

Conversion factor

1000 x 1000 (g/g to mg/L)

Weight of octanol

60,46 g

(50 g with a volumic mass of 0,827 g/cm3)

The concentration of the test item in the octanol is (35.5 x 1000 x 1000)/60.46 = 587 165 mg/L

Therefore, the Log P of test item is

Solubility in water = 75 mg/L

Solubility in octanol = 587 165 mg/L

log P = log (conc in oct / conc in water) = 3.9

Conclusions:
The comparison of measured solubilities in octanol and in water separately (as advised in the R7a ECHA REACH Guideline) by spectrometry gives an extrapolated log Kow value for Sepisol Fast Yellow MG-F of 3.9.

Description of key information

Log Kow by the ratio of the measured solubilities in octanol and in water separately

Key value for chemical safety assessment

Log Kow (Log Pow):
3.9
at the temperature of:
22 °C

Additional information