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EC number: 700-717-5 | CAS number: -
Summary of the mean values / challange
Scale of the evaluation:
0 = no reaction
0.5 = ± slight, patchy erythema
1 = slight, confluent or moderate patchy erythema
2 = moderate erythema
3 = severe erythema or edema
After two induction treatments (test substance 100%) some of the test animals showed partly moderate to severe erythema. Therefore, the 3rd induction treatment was performed with a 50% dilution, which caused no primary skin irritation. 24 hours after the challenge treatment (test substance 75%) slight patchy erythema was observed in the test animals (12/20). After 48 hours the symptoms were significantly reduced (6/20). However, since this concentration was used in the challenge in the range finding test, no primary skin irritation was caused and also there were no findings in the control group in the challenge, it was assumed by the study authors that this is a sensitizing effect.
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