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Test results for ADONA, the ammonium salt, are also reported for DONA free acid. ADONA exists in dissociated form, as ammonium and DONA anion, in aqueous solution. The ADONA toxicity tests are functionally tests of the combined toxicity of ammonium and DONA anion. The hydrolysis half-life of MeDONA in pure water and ambient temperature was determined to be 2.68 ± 1.63 minutes. The hydrolysis products are methanol and DONA free acid. MeDONA will therefore not exist for more than a few minutes in aqueous solution, being converted totally to methanol and DONA in any environmental system Aquatic toxicity testing with MeDONA as the starting material would be conducted at near-neutral pH. Given a pKa of ca. 2, the organisms would also be exposed to DONA anion and a small amount of methanol if these studies were conducted. Methanol is a REACH-registered substance of minimal hazard to aquatic systems, and is not considered further. Because no toxicity was observed with ADONA, there is no confounding of DONA toxicity with ammonium toxicity, and the ADONA results are directly applicable to MeDONA.