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EC number: 213-243-4
CAS number: 931-87-3
no further information
In an acute oral toxicity study, groups of fasted rats,
(5/sex/dose) were given a single oral dose (gavage) of Cyclooctene (10.0
mL/kg bw dilution in paraffine) and were observed for 14 days. Oral LD50
was 4550 mg/kg bw. The signs of toxicity observed about 90 minutes
after application were ruffled fur, ataxia, prone position, crouched
posture, staggering gait, agitation, spasms, tremor and sedation. With
the animals surviving the treatment, the findings had disappeared after
nine days at the latest. Dissection post mortem revealed redness of the
gastro-intestinal mucosa and a deep-red or grey discoloration of the
Among the animals surviving the treatment, at the end of the
period of observation 2 animals from the 3980 mg/kg bw dose group showed
erythema of the small intestinal mucosa and fusion of organs in the
abdominal cavity, and one animal of the highest dose group showed fluid
accumulation in the fallopian tube. In all other cases, dissection
revealed no organ findings
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