Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 935-783-6 | CAS number: -
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
In accordance with Regulation (EC) 1907/2006, Column 2 of Annex IX, section 9.3.2, bioaccumulation testing in aquatic species is not required as the substance has a low potential for bioaccumulation (the log Kow is < 3).
Key value for chemical safety assessment
Additional information
In accordance with Regulation (EC) 1907/2006, Column 2 of Annex IX, section 9.3.2, bioaccumulation testing in aquatic species is not required as the reaction mass has a low potential for bioaccumulation which is indicated by a log Kow < 3.
Bioaccumulation of one component of the reaction mass, 4-chloro-m-cresol (CAS No. 59-50-7), was investigated in two supporting studies. This information is included to improve the assessment of the reaction mass.
The first supporting study (MITI, 1992) was carried out equivalent to OECD guideline 305 C and used carp (Cyprinus carpio) as test organism. In a flow-through system, nominal concentrations of 2 and 20 mg/L were tested. The resulting BCF values ranged from 5.5 to 11 for the low and from 6.7 to 13 for the high test concentration.
The second supporting study (Jennings et al., 1996) was a well-documented exposure/uptake and depuration experiment under semi-static conditions. The test organisms blue mussel (Mytilus edulis) and yellowtail horse mackerel (Trachurus novaezelandiae) were exposed to three test concentrations (1, 10 and 100 µg/L) for one week followed by one week of depuration in clean water.Only the individuals exposed to a concentration of 100 µg CMK/L accumulated the test substance above trace amounts. Bioaccumulation at this test concentration proceeded rapidly; a plateau concentration was already reached after 6 h (mussels) and 12 h (fish).The BCF values were 37.75 for the mussel and 120.8 for the fish. The fishaccumulated to a higher extent than the mussel however, residues could only be detected in the muscle tissue and not in the livers. After transfer to clean seawater CMK was depurated rapidly with only traces remaining after 12 h in both mussel and fish.
In conclusion, bioconcentration factors vary between 5.5 and 120.8 and after the end of exposure the substance is rapidly depurated from the test organisms, indicating a low potential for bioaccumulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
