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EC number: 278-860-3
CAS number: 78182-00-0
The test item DMAC Trocken Flüssig was tested for its mutagenic
potential in Salmonella typhimurium and Escherichia coli, in the
standard plate test (SPT) and the preincubation test (PIT), according to
the OECD TG 471 (1997). The tester strains were: TA1535, TA100, TA1537,
TA98 and E. coli WP2 uvrA. Testing was done in absence and presence of
S9 mix. Negative and positive controls were included.The test
concentrations were as follows:
- 1st Experiment (all strains, standard plate test with and
without S-9 mix, 3 plates/dose): 0; 20; 100; 500; 2500 and 5000 µg/plate
- 2nd Experiment (all strains, preincubation test with and without
S-9 mix, 3 plates/dose): 0; 20; 100; 500; 2500 and 5000 µg/plate
When tested in all strains mentioned above under SPT and PIT conditions,
with and without S9 mix, the test item did not induce an increase in
his+ or trp+ revertant colonies at concentrations up to 5000 µg/plate. A
slight cytototoxic effect was observed both in the SPT and the PIT from
2500 μg/plate onward. No test item precipitation was observed within the
concentration range tested, with and without S9-mix. Referring to
controls, the results of the negative as well as the positive controls
performed in parallel corroborated the validity of this study, since the
values fulfilled the acceptance criteria of this study. Thus,
under the experimental conditions chosen, the test item DMAC Trocken
Flüssig is not mutagenic in bacteria.
The test item was tested for bacterial mutagenicity according to the
OECD TG 471 (1997). Because of negative results, there is no need to
classify the test item for mutagenicity according to the EU Directive
67/548/EC and according to the CLP Regulation 1272/2008.
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