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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary source only

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Chloroacetic acid, CAS No: 79-11-8
Author:
OECD SIDS
Year:
1996
Bibliographic source:
http://www.inc hem.org/doc uments/sids/s ids/79118.pdf
Reference Type:
publication
Title:
Empirical determination of the MAC value for chloracetic acid in production plant atmospheres
Author:
Maksimov, G.G. and Dubinina, O.N.
Year:
1974
Bibliographic source:
Labour Hygiene and Occupational Diseases, 18, 32

Materials and methods

Principles of method if other than guideline:
The test substance was topically applied to the skin of rabbits to evaluate irritating and/or corrosive properties towards the skin.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Chloroacetic acid
EC Number:
201-178-4
EC Name:
Chloroacetic acid
Cas Number:
79-11-8
Molecular formula:
C2H3ClO2
IUPAC Name:
chloroacetic acid
Details on test material:
- Name of test material (as cited in study report): Chloracetic acid
- Analytical purity: no data

Test animals

Species:
rabbit
Strain:
not specified

Test system

Amount / concentration applied:
up to 100%

Results and discussion

In vivo

Irritant / corrosive response data:
Concentrated chloracetic acid was highly corrosive to the skin of rabbits. A concentration of 0.05% chloracetic acid was shown to be irritating.

Applicant's summary and conclusion