2-Propenoic acid, 2-methyl-, monoester with 1,2-propanediol, reaction products with dipropylene glycol and 1,1'-methylenebis[isocyanatobenzene]

Endpoint summary

Additional information

Experimental data investigating the toxicity of UMA 121 to terrestrial organisms are available for three different taxonomic groups (soil macroorganisms, terrestrial plants and soil microorganisms). They are representative for the three main ecological processes in the terrestrial ecosystem (primary production (plant), breakdown of organic matter (earthworm), re-cycling of nutrients (soil microorganisms). Moreover, different exposure pathways are covered by the selected test species. Plants and soil microorganisms are mainly exposed to the substance via the soil pore water whereas earthworms are exposed via soil pore water as well as ingestion of soil material).
The substance is expected to strongly adsorb to soil particles based on its log Kow of 3.9 - 7 and a log Koc of > 4. Furthermore, the substance is not readily biodegradable. Thus, in accordance with section R.7.11.5.3. of Chapter R.7c of the ECHAGuidance on information requirements and chemical safety assessment (ECHA, 2014) long-term tests were conducted in order to assess the toxicity of UMA 121 to terrestrial organisms.UMA 121 is expected to mainly adsorb to soil particles(high adsorption potential) and only to a minor extent remains in the soil pore water (low water solubility). Thus, the bioavailability of the substance for plants and soil microorganisms is limited whereas earthworms might be exposed via ingestion of particle-bound substance.
UMA 121 is a colorless solid resin at ambient conditions. In order to incorporate the test item into the soil it was ground under cooled conditions (2-8 °C) to a very fine powder. Due to the very low water solubility of the test substance, appropriate amounts of the test item were mixed directly with quartz sand in order to prepare the exposure concentrations.
All available studies did not indicate a hazard to terrestrial organisms. No effects on mortality and reproduction of earthworms (Eisenia fetida) were recorded up to a concentration of 1000 mg/kg soil dry weight in a GLP study according to OECD 222 (Friedrich, 2016).
A limit test with a maximum concentration of 1000 mg/kg soil dry weight did not show any effects on seedling emergence and plant growth of two monocotyledonous (Avena sativa and Allium cepa) and four dicotyledonous plants (Brassica napus, Lycopersicon esculentum, Cucmis sativus and Glycine max). This study was performed according to OECD 208 (GLP; Friedrich, 2016).
The effects of UMA 121 on soil microorganisms were tested in a study according to OECD 216 (GLP; Schulz, 2016). UMA 121 was not found to have effects on the nitrogen transformation rate in soil up to a concentration of 1000 mg/kg soil dry weight.
In conclusion, UMA 121 is not hazardous to terrestrial organisms based on reliable experimental studies for three different taxonomic groups.