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EC number: 229-554-3 | CAS number: 6607-34-7
The limit of detection of adipic acid was about 4 µg/ml (27 nmol/ml; 27 µM). This means that hydrolysis of only 1% of Adipic acid, cyclic ester with diethyleneglycol could be detected with this method.
1)-2) After a 4h incubation of Adipic acid, cyclic ester with diethyleneglycol in phosphate buffer or hydrochloric acid, no hydrolysis of could be detected . Therefore a non-enzymatic hydrolysis either at neutral pH or at a low pH-value simulating conditions in the stomach can not be anticipated.
3) Hydrolysis of Adipic acid, cyclic ester with diethyleneglycol with corresponding formation of adipic acid could be demonstrated at both concentrations tested. The hydrolysed portion increased with the duration of the incubation and the concentration used.
Table: Enzymatic hydrolysis of Adipic acid, cyclic ester with diethyleneglycol in rat plasma.
Nominal conc. [µg/ml]
Mean adipic acid [µg/ml]; n=2
Corresponding % adipic acid, cyclic ester with diethyleneglycol hydrolysed
In control experiments it could be shown that Adipic acid, cyclic ester with diethyleneglycol was considerably bound to plasma proteins. The fact that enzymatic ester hydrolysis is more pronounced at higher concentrations may therefore result from saturation of protein binding and a consequently higher free plasma concentration.
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