Registration Dossier
Registration Dossier
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EC number: 204-876-7 | CAS number: 128-04-1
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key study: Test method according to OECD Guideline 203. The 96h-LC50 for sodium dimethyldithiocarbamate in Poecilia reticulata was determined to be 2.6 mg/l.
Supporting study: No guideline followed. No analytical monitoring was made. The NOEC based on notochord distortion was determined to be 4 ppb (0.004 mg/l). The LC50 was reported to be between 400 and 4000 ppb (equivalent to 0.4 and 4 mg/l, respectively).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 2.6 mg/L
Additional information
Key study: An acute toxicity test with sodium dimethyldithiocarbamate on Poecilia reticulata was performed in accordance with the OECD Guideline 203. Fishes were exposed to different concentrations of the test substance over a period of 96 hours in a semi-static system. The 96h-LC50 in Poecilia reticulata was determined to be 2.6 mg/l.
Supporting study: In the present study, developing zebrafish were exposed to sodium dimethyldithiocarbamate concentrations of 4, 40, 400 ppb and 4 ppm from 4 to 24 h post-fertilization. Proper axis formation in the exposed embryos was examined using notochord formation as a morphological marker. Besides, in situ hybridization of developmental markers for collagen, muscle and body axis formation was performed. The medial lethal dose (LC50) for the exposed animals was also determined. Sodium dimethyldithiocarbamate elicited notochord distortions with notochord NOEC of 4 ppb (0.004 mg/l). In situ hybridation of developmental markers was perturbed well after cessation of the treatment. The animals developed normally without other overt morphological effects. The LC50 was determined to be between 400 and 4000 ppb (equivalent to 0.4 and 4 mg/l, respectively).
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