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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Adopted according to OECD SIDS (publicly available peer reviewed source). Original document not available.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
SIDS Initial Assessment Report For SIAM 16 (Triethyl Phosphite), 2003 Paris.
Author:
OECD
Year:
2003
Bibliographic source:
UNEP Publications
Reference Type:
publication
Title:
Acute evaluation of triethyl phosphite.
Author:
Kinkead ER, Wolfe RE, Bunger SK, Pollard DL
Year:
1992
Bibliographic source:
Acute Toxic. Data 1, 217-218. Cited in SIDS Initial Assessment Report For SIAM 16 (Triethyl Phosphite), 2003 Paris.

Materials and methods

Principles of method if other than guideline:
Compound was applied to 5 rabbits per sex and dose to an area of approx. 30% total body surface at 2.0, 2.5 and 3.0 g/kg bw and was covered with gauze bandage, plastic wrap, and elastic tape. After 24 h the covers were removed, wiped clean, and observed for 14 days.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Purity: no data.

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female
Details on test animals and environmental conditions:
Weight: 2-3 kg

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
Compound was applied to an area approx. 30% total body surface and was covered with gauze bandage, plastic wrap, and elastic tape.After 24 h the covers were removed, wiped clean, and observed for 14 days.
Duration of exposure:
24 h
Doses:
2.0, 2.5 and 3.0 g/kg bw
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: no data
- Other examinations performed: no data

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
2 800 mg/kg bw
Based on:
test mat.
Sex:
female
Dose descriptor:
LD50
Effect level:
> 3 000 mg/kg bw
Based on:
test mat.
Mortality:
No data.
Clinical signs:
No data.
Body weight:
No data.
Gross pathology:
No data.

Applicant's summary and conclusion