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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Adopted according to OECD SIDS (publicly available peer reviewed source). Original document not available.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
SIDS Initial Assessment Report For SIAM 16 (Triethyl Phosphite), 2003 Paris.
Author:
OECD
Year:
2003
Bibliographic source:
UNEP Publications
Reference Type:
publication
Title:
Acute evaluation of triethyl phosphite.
Author:
Kinkead ER, Wolfe RE, Bunger SK, Pollard DL
Year:
1992
Bibliographic source:
Acute Toxic. Data 1, 217-218. Cited in SIDS Initial Assessment Report For SIAM 16 (Triethyl Phosphite), 2003 Paris.

Materials and methods

Principles of method if other than guideline:
Ten Fischer 344 rats per sex and dose were exposed to an aerosol for 6 h. Exposure MMAD´s were between 1.6 and 3.5 μm. Aerosol concentrations were produced using a Solosphere (R) nebulizer and were analysed by GC. Aerosol measurement was performed by a cascade impactor. Clinical signs, body weight gain and LC50 were reported. No details on doses were given.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
Triethylphosphite
IUPAC Name:
Triethylphosphite
Details on test material:
Purity: no data.

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male/female
Details on test animals or test system and environmental conditions:
Age: 9-11 weeks.

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
not specified
Vehicle:
other: undiluted
Details on inhalation exposure:
Exposure MMAD´s were between 1.6 and 3.5 μm.
Aerosol concentrations were produced using a Solosphere (R) nebulizer and were analysed by GC.
Aerosol measurement was performed by a cascade impactor.
Analytical verification of test atmosphere concentrations:
yes
Remarks:
gas chromatographic analysis
Duration of exposure:
6 h
Concentrations:
No data.
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight gain

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LC50
Effect level:
11.62 mg/L air
Based on:
test mat.
95% CL:
10.08 - 12.76
Exp. duration:
6 h
Sex:
female
Dose descriptor:
LC50
Effect level:
11.06 mg/L air
Based on:
test mat.
Exp. duration:
6 h
Remarks on result:
other: Confidence limits could not be calculated due to reversals in mortality curve.
Mortality:
No details were reported. Most deaths occured within 24 hours following treatment.
Clinical signs:
other: Signs of toxic stress included eye and upper respiratory irritation, salivation and rapid, shallow breathing. Surviving animals appeared normal to conclusion of observation period.
Body weight:
Subnormal weight gain of survivors during the 14-days observation period.
Gross pathology:
Dead animals: restricted to diffuse lung congestion.

Applicant's summary and conclusion