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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Adopted according to OECD SIDS (publicly available peer reviewed source). Original document not available.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
SIDS Initial Assessment Report For SIAM 16 (Triethyl Phosphite), 2003 Paris.
Author:
OECD
Year:
2003
Bibliographic source:
UNEP Publications
Reference Type:
publication
Title:
Acute evaluation of triethyl phosphite.
Author:
Kinkead ER, Wolfe RE, Bunger SK, Pollard DL
Year:
1992
Bibliographic source:
Acute Toxic. Data 1, 217-218. Cited in SIDS Initial Assessment Report For SIAM 16 (Triethyl Phosphite), 2003 Paris.

Materials and methods

Principles of method if other than guideline:
Ten Fischer 344 rats per sex and dose were exposed to an aerosol for 6 h. Exposure MMAD´s were between 1.6 and 3.5 μm. Aerosol concentrations were produced using a Solosphere (R) nebulizer and were analysed by GC. Aerosol measurement was performed by a cascade impactor. Clinical signs, body weight gain and LC50 were reported. No details on doses were given.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Purity: no data.

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male/female
Details on test animals and environmental conditions:
Age: 9-11 weeks.

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
not specified
Vehicle:
other: undiluted
Details on inhalation exposure:
Exposure MMAD´s were between 1.6 and 3.5 μm.
Aerosol concentrations were produced using a Solosphere (R) nebulizer and were analysed by GC.
Aerosol measurement was performed by a cascade impactor.
Analytical verification of test atmosphere concentrations:
yes
Remarks:
gas chromatographic analysis
Duration of exposure:
6 h
Concentrations:
No data.
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight gain

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LC50
Effect level:
11.62 mg/L air
Based on:
test mat.
95% CL:
10.08 - 12.76
Exp. duration:
6 h
Sex:
female
Dose descriptor:
LC50
Effect level:
11.06 mg/L air
Based on:
test mat.
Exp. duration:
6 h
Remarks on result:
other: Confidence limits could not be calculated due to reversals in mortality curve.
Mortality:
No details were reported. Most deaths occured within 24 hours following treatment.
Clinical signs:
other: Signs of toxic stress included eye and upper respiratory irritation, salivation and rapid, shallow breathing. Surviving animals appeared normal to conclusion of observation period.
Body weight:
Subnormal weight gain of survivors during the 14-days observation period.
Gross pathology:
Dead animals: restricted to diffuse lung congestion.

Applicant's summary and conclusion