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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Adopted according to OECD SIDS (publicly available peer reviewed source). Original document not available.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
SIDS Initial Assessment Report For SIAM 16 (Triethyl Phosphite), 2003 Paris.
Author:
OECD
Year:
2003
Bibliographic source:
UNEP Publications
Reference Type:
publication
Title:
Acute evaluation of triethyl phosphite.
Author:
Kinkead ER, Wolfe RE, Bunger SK, Pollard DL
Year:
1992
Bibliographic source:
Acute Toxic. Data 1, 217-218. Cited in SIDS Initial Assessment Report For SIAM 16 (Triethyl Phosphite), 2003 Paris.

Materials and methods

Principles of method if other than guideline:
Ten Fischer 344 rats per sex and dose were treated with 1000, 1500, 2000, 2500, 3000 and 4000 mg/kg bw by gavage. Clinical signs were observed and LD50 was determined.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Purity: no data

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male/female
Details on test animals and environmental conditions:
Animals were fasted prior to dosing.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: Mazola corn oil
Details on oral exposure:
The test substance was mixed with Mazola corn oil and administered at constant volumes of 1% body weight.
Doses:
1000, 1500, 2000, 2500, 3000 and 4000 mg/kg bw
No. of animals per sex per dose:
10
Details on study design:
Check for mortality and observations was performed throughout the 14 day observation period.

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
2 470 mg/kg bw
Based on:
test mat.
95% CL:
2 220 - 2 730
Sex:
female
Dose descriptor:
LD50
Effect level:
1 840 mg/kg bw
Based on:
test mat.
95% CL:
1 630 - 2 140
Mortality:
Mortality occured. Most deaths occured within 24 hours after dosing. no further details.
Clinical signs:
Rapid breathing and tremors were observed prior to death.
Body weight:
Survivors gained weight during observation period.

Applicant's summary and conclusion