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Diss Factsheets

Administrative data

Endpoint:
skin sensitisation
Remarks:
in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: information from migrated NONS file as per inquiry # [06-0000014790-71-0000], permission to refer granted by ECHA

Data source

Reference
Reference Type:
other: body responsible for the test
Title:
Unnamed
Year:
2011

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Maximization test according to Magnusson and Kligman Annex V B6
GLP compliance:
yes
Type of study:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
EC Number:
401-990-0
EC Name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
Cas Number:
106990-43-6
Molecular formula:
C132H250N32
IUPAC Name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine

In vivo test system

Test animals

Species:
other: albino guinea pig
Strain:
other: Pirbright white strain DHP

Study design: in vivo (non-LLNA)

Induction
Concentration / amount:
First induction (intrademal injection): 1% in Sesame oil and adjuvant saline mixture.
Second induction (epidermal application): 10% in vaseline

concentration of test material and vehicle used for each challenge: 0.3% in vaseline
Challenge
Concentration / amount:
First induction (intrademal injection): 1% in Sesame oil and adjuvant saline mixture.
Second induction (epidermal application): 10% in vaseline

concentration of test material and vehicle used for each challenge: 0.3% in vaseline
No. of animals per dose:
Number of animals in test group: 20
Number of animls in negative control group: 10

Results and discussion

In vivo (non-LLNA)

Results
Reading:
other: n/a
Group:
test chemical
Dose level:
n/a
No. with + reactions:
10
Total no. in group:
20
Remarks on result:
other: Reading: other: n/a. Group: test group. Dose level: n/a. No with. + reactions: 10.0. Total no. in groups: 20.0.

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU

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