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Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: information from migrated NONS file as per inquiry # [06-0000014790-71-0000], permission to refer granted by ECHA

Data source

Reference
Reference Type:
other: body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD guidelines for testing of Chenicals, Guideline No.417; "Toxicokinetics" adopted April 4, 1984
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
EC Number:
401-990-0
EC Name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
Cas Number:
106990-43-6
Molecular formula:
C132H250N32
IUPAC Name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
Radiolabelling:
yes

Test animals

Species:
other:

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: com oil
Details on exposure:
a single dose via oral gavage
No. of animals per sex per dose / concentration:
Male: 4 animals at CA 50mg/kg
Male: 4 animals at CA 1000mg/kg
Details on dosing and sampling:
The purpos of this study is to obtain information on the absorption, distribution and excretion (ADE) of 14C-chimassorb 119 as a function of oral dosage level. This information may be used as an aid in the evaluation and interpretation of other toxicology studies and the study results amy contribute to provide a rational basis of toxicological ris assessment in man.

Results and discussion

Any other information on results incl. tables

After oral dose of 50 and 1000mg of 14C-chimassorb 119 per kg body weight, the excretion of total radioactivity in virtually complete within 96 hours after administration. Radioactivity is excreted nearly entirely via faeces (96 -99% of recovered radio label). Renal excretion is very low (0.28 -0.60% of the dose), and excretion of radio activity via expired arie negligible (<=0.01% of the dose). There is hardly any retention of radio activity in tissues. There was no significant bioconcentration or accumulation in any of the organs in vestigated.

Applicant's summary and conclusion