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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: restriction: early study report; short study description. Otherwise scientifically reliable

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1966

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: according to BASF-internal standard
Principles of method if other than guideline:
Method: other: Estimation of the approximative LD50 value according to BASF-internal standard
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(2-(2-butoxyethoxy)ethoxy)ethanol
EC Number:
205-592-6
EC Name:
2-(2-(2-butoxyethoxy)ethoxy)ethanol
Cas Number:
143-22-6
Molecular formula:
C10H22O4
IUPAC Name:
2-[2-(2-butoxyethoxy)ethoxy]ethanol
Details on test material:
Test substance: as prescribed by 1.1 - 1.4

Test animals

Species:
rat
Strain:
other: US rats
Sex:
male/female
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
Observation period: 14 days
Test substance given as 2, 20 and 30% aqueous solution
Doses:
200, 1600, 3200, 4000, 5000, 6400 ccm/kg
No. of animals per sex per dose:
10
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
5 170 mg/kg bw
Based on:
test mat.
Mortality:
see table below
Clinical signs:
Staggering, abdominal and lateral position, narcosis; female rats: sometimes bloody urine
Gross pathology:
sometimes bloody urine, several kidney damage

Any other information on results incl. tables

Dose (cmm/kg) 

 Conc. (%)

 No. of animals

 Dead animals within            

 

 

 

 1 hour

 24 hours

 48 hours

 7 days

 14 days

 6400

 30

 10

 5/10

 9/10

 9/10

 9/10

 9/10

 5000

 30

 10

 0/10

 5/10

 5/10

 5/10

 5/10

 

 30

 10

 1/10

 3/10

 3/10

 3/10

 3/10

 4000

 30

 10

 0/10

 1/10

 1/10

 1/10

 1/10

 

 30

 10

 2/10

 4/10

 5/10

 5/10

 5/10

 3200

 30

 10

 1/10

 1/10

 2/10

 2/10

 2/10

 1600

 20

 10

 0/10

 0/10

 0/10

 0/10

 0/10

 200

 2

 10

 0/10

 0/10

 0/10

 0/10

 0/10

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
In a reliable acute oral toxicity study where original data is available, male and female rats were subjected to doses of up to 6400ml/kg of 2-(2-(2-butoxyethoxy)ethoxy)ethanol and subsequently observed for a period of 14 days. An LD50 value of ~5170mg/kg was obtained.
Executive summary:

In a reliable acute oral toxicity study where original data is available, male and female rats were subjected to doses of up to 6400ml/kg of 2-(2-(2-butoxyethoxy)ethoxy)ethanol and subsequently observed for a period of 14 days. An LD50 value of ~5170mg/kg was obtained.