Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 907-235-6 | CAS number: -
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- year of publication: 2005
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No substance specific information, only general information on aldehydes available (review)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test material
- Reference substance name:
- aldehydes in general
- IUPAC Name:
- aldehydes in general
- Details on test material:
- no data
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- other: no data
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: diverse
- Vehicle:
- not specified
- Duration and frequency of treatment / exposure:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
no data
- No. of animals per sex per dose / concentration:
- no data
- Control animals:
- not specified
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
Undecanal is primarily oxidised to undecanoic acid which is utilised in the fatty acid oxidation and intermediary metabolism. Undecanoic caid and conjugates thereof may also appear in urine. - Executive summary:
According to the data presented in this review aldehydes are mainly oxidised to its corresponding acid by, predominantly, aldehyde dehydrogenases, a cytosolic enzyme. Acids may then be oxidised and degraded. Alternatively acids may be conjugated with glycine to form hippuric acides. Another metabolism pathway is reduction to the respective alcohols by cytosolic, NAD+-dependent alcohol dehydrogenases, and conjugation of the low molecular weight aldehydes with glutathione, followed by further metabolic steps. The main excretion pathway for remaining aldehyde metabolites is the urine (O'Brien, 2005).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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