Registration Dossier
Registration Dossier
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EC number: 616-466-9 | CAS number: 77501-63-4
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- genetic toxicity in vivo
- Remarks:
- Type of genotoxicity: other: in vivo: DNA binding assay and DNA covalent binding in mouse liver
- Type of information:
- other:
- Adequacy of study:
- supporting study
- Study period:
- 2012
- Rationale for reliability incl. deficiencies:
- other: Short description on comprehensive studies available via the internet by US EPA and pubchem.ncbi.nlm.nih.gov
Data source
Reference
- Reference Type:
- secondary source
- Title:
- lactofen - Compound Summary (CID 62276)
- Author:
- US EPA and Pubchem NCBI
- Year:
- 2 012
- Bibliographic source:
- http://iaspub.epa.gov/apex/pesticides/f?p=chemicalsearch:3:0::no:1,3,31,7,12,25:p3_xchemical_id:2666
Materials and methods
- Principles of method if other than guideline:
- short summary on different studies
- Type of assay:
- other: In vitro: Salmonella typhimurium/mammalian microsome mutagenicity assay, mammalian cytogenetic assay and unscheduled DNA synthesis,
Test material
- Reference substance name:
- (2-ethoxy-1-methyl-2-oxoethyl)-5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate
- EC Number:
- 616-466-9
- Cas Number:
- 77501-63-4
- Molecular formula:
- C19H15ClF3NO7
- IUPAC Name:
- (2-ethoxy-1-methyl-2-oxoethyl)-5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate
- Test material form:
- not specified
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- other: short summary on different experiments
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: in vitro / in vivo studies
Examinations
- Tissues and cell types examined:
- see summary
Results and discussion
Any other information on results incl. tables
The guideline and non-guideline studies indicate that lactofen is neither genotoxic nor mutagenic.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
- Executive summary:
Executive summary is derived from the following internet links on 2012 -11 -09.
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=62276#x321
http://www.epa.gov/iris/subst/0280.htm
References of individual studies:
PPG Industries. 1985b. MRID No. 00132883, 00150329. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
• /GENOTOXICITY/ The guideline and non-guideline studies indicate that lactofen is neither genotoxic nor mutagenic. Equivocal (probably negative) results were observed in an in vivo DNA binding assay with radiolabeled lactofen. Salmonella typhimurium/mammalian microsome mutagenicity assay: negative with and without S-9. In vitro cytogenetic assay with Chinese hamster ovary (CHO) cells: negative for clastogenic effects with and without S-9. In vitro unscheduled DNA synthesis in primary mouse and rat hepatocytes: negative. In vivo DNA covalent binding in mouse liver: low level of binding (equivocal, probably negative).
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