Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 616-466-9 | CAS number: 77501-63-4
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
BCF of (2-Ethoxy-1-methyl-2-oxoethyl)-5-[2-chloro-4-(trifluoromethyl) phenoxy]-2-nitrobenzoate is 220-380 in whole fish. The substance is eliminated from the fish with an initial half-live of less than 1 d in fish when environmental supply is terminated
Key value for chemical safety assessment
- BCF (aquatic species):
- 380 L/kg ww
Additional information
The bioconcentration potential of (2-Ethoxy-1-methyl-2-oxoethyl)-5-[2-chloro-4-(trifluoromethyl) phenoxy]-2-nitrobenzoate was determined in bluegill sunfish (Lepomis macrochirus) in a 44 d flow-through study with a constant concentration of 0.0087 mg/L 14C-labelled test item for a 30 d exposure period. Radioanalysis of whole fish, fillet and visceral portions throughout the exposure period indicated a rapid uptake
of 14C-(2-Ethoxy-1-methyl-2-oxoethyl)-5-[2-chloro-4-(trifluoromethyl) phenoxy]-2-nitrobenzoate. Bioaccumulation reached steady state after 3 d. At d 30 concentrations of 14C-(2-Ethoxy-1-methyl-2-oxoethyl)-5-[2-chloro-4-(trifluoromethyl) phenoxy]-2-nitrobenzoate were 2.2-3.7 ppm for whole fish, 0.24-0.91 ppm for fillet and 3.7-7.3 ppm for viscera. Elimination of 14C-(2-Ethoxy-1-methyl-2-oxoethyl)-5-[2-chloro-4-(trifluoromethyl) phenoxy]-2-nitrobenzoate was measured for 14 d by placing the fish into clean water. Clearance was 99, 94 and 99 % w/w for whole
fish, fillet and viscera, respectively .
Uptake-depuration was modeled for whole fish using a two-compartment kinetic model yielding a bioconcentration factor (BCF) of 220. With measured values of the 30th d, the BCF was 380 (whole body w.w.)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
