Manganese oxalate

Endpoint summary

Description of key information

Solubility in Water: 285-370 mg/L at 20°C
Solubility in n-Octanol: closely to 0 g/L
log Pow: << 0
Acute oral toxicity: LD50: >2000  mg/kg b.w., no lethality up to the highest dose tested
Acute dermal toxicity: LD50 >2000 mg/kg b.w., no lethality up to the highest dose tested
Skin corrosion/irritation: not corrosive, not irritant
Eye corrosion/irritation: not corrosive, not irritant
Skin sensitisation: not skin sensitizing
Repeated dose toxicity: NOAEL: 1000 mg/kg b.w., no adverse effects up to the highest dose tested (28-d Study, Reproduction/Developmental Screening Test)
Genotoxicity: negative (AMES, HPRT, in vitro CA), Cytotoxicity: yes
Reproductive Toxicity (Fertility and Developmental Toxicity): NOAEL: 1000 mg/kg b.w.  no adverse effects up to the highest dose tested (Reproduction/Developmental Screening Test)

Key value for chemical safety assessment

Bioaccumulation potential:

no bioaccumulation potential

Additional information

Toxicokinetic behavior (absorption - distribution - metabolism - excretion) has not been investigated experimentally. Thus the discussion is based on the findings in several toxicity studies together with the physico-chemical properties of the substance.

Available single and repeated dose toxicity studies didn't reveal any adverse effects after oral or dermal exposure. In particular no signs of toxic properties specific for Manganese and its salts (Mn) or for Oxalate compounds (Ox) such as Neurotoxicity (Mn) or Nephrotoxicity (Ox), or lethality (Oxalic acid, in acute toxicity studies) were observed in any of the available studies comprising macroscopic and microscopic examinations of kidneys, clinical chemistry and blood parameters and clinical observations (daily, weekly and during the functional observational battery).

Studies primarily aiming at local effects (skin irritation, acute dermal toxicity, eye irritation, skin sensitization) didn't reveal signs of relevant interaction with living tissues or skin absorption.

In vitro studies for mutagenicity came out with negative results (Ames, HPRT, CA) with and without metabolic activation. However, some cytotoxicity exists (HPRT, CA) at a similar extent, when Chinese Hamster Cells were incubated with and without metabolic activation (HPRT, Pre-Test Toxicity).

Analyses of physico-chemical properties yield a relatively low solubility in water (285-370 mg/L at 20°C) as compared to Manganese Chloride (739 g/L), Manganese Nitrate (1390 g/L), Manganese Sulfate (629 g/L), Oxalyc Acid (108 g/L), Potassium Oxalate (364 g/L) or Sodium Oxalate (34.1 g/L). In n-octanol, Manganese Oxalate was practically insoluble (closely 0 g/L). The logPow was calculated to be << 0.

From this one can infer that Manganese Oxalate:

- is practically nontoxic after acute and repeated exposure, and/or

- is not bioavailable in relevant quantities after oral or dermal exposure,

- is not metabolized or hydrolyzed to toxic degradation products,

- is nontoxic to bacteria but toxic to mammalian cells when tested in vitro, however this is not an issue in vivo,

- undergoes no shift of cell toxicity when incubated with metabolic activation, meaning that Manganese Oxalate didn't decompose to metabolites of higher or lower cell toxicity,

- has no potential for bioaccumulation.