Registration Dossier
Registration Dossier
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EC number: 940-422-0 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Additional information
GENERAL
Glucamides are biotransformed by cleavage of the amide group and subsequently by metabolisation of the fatty acid and meglumine. The different fatty acids formed are further metabolized by beta oxidation to acetate. From the available ready biodegradation tests of the different Glucamides it is known that the metabolic rate decreases with longer carbon chain length. Based on this observation using a result of a biodegradation test with a Glucamide with longer carbon chain length for a Glucamide with lower carbon chain length for read across is justified.
BIODEGRADATION IN WATER: SCREENING TESTS
The registration substance is readily biodegradable in an CO2 Evolution test (Sturm test) according OECD Guideline 301B (see IUCLID Section 5.2.1).
BIODEGRADATION IN WATER AND SEDIMENT: SIMULATION TESTS
A. Biodegradation in Sewage Treatment Plant
A valid Sewage treatment plant simulation test according the OECD Guideline 303A is not available for the registration substance. But for C18 C18u Glucamide a study with 14C labelled substance was carried out. For the reasons given above this study can be used for read across to the registration substance as this can be regarded as a worst case for the lower carbon chain length of the registration substance. Based on this study the elimination of the parent compound is 99% (1% to effluent, 3.8% to activated sludge, 95.2% biodegradation) see IUCLID Section 5.2.2.
B. Biodegradation in anaerobic Sewage sludge
In a simulation test to assess the biodegradability of chemicals discharged in waste water which corresponds to the OECD Guideline 314C (Biodegradation in Anaerobic Digester Sludge) rapid biodegradation under anaerobic conditions was observed for the the C12 homologue of Glucamide 1214. The derived half-live from the measurement of 14CO2 formed is 2 -6d at 20°C (see IUCLID Section 5.2.2).
BIODEGRADATION IN SOIL
The C12 homologue of Glucamide 1214 is rapidly biodegraded in aerobic soil with a half-live of ca. 10d at 20°C.
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