Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 February 2009 - 08 May 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study has been performed according to OECD and EC guidelines and according to GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Details on test material:
- - Name of test material (as cited in study report): Custom Red #2
- Substance type: violet powder
- Physical state: solid
- Purity test date: no data
- Lot/batch No.: C50APR0805D
- Expiration date of the lot/batch: 08 January 2011
- Stability under storage conditions: stable
- Storage condition of test material: at room temperature in the dark
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 7.7
- Temp.:
- 25 °C
- pH:
- ca. 7
Any other information on results incl. tables
In the chromatogram of the test substance solution, five components related to the test substance were observed. No strong hydrophobic compounds were observed in the gradient of the analytical method.
The results of the HPLC method (neutral pH) are given in the Table:
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Applicant's summary and conclusion
- Conclusions:
- The Pow and log Pow value of the test substance with a peak area of > 1% determined by the HPLC method are given below. The test was performed with a THF soluble fraction of the test substance. The results were obtained by extrapolation of the curve.
Compound 1: Pow: 5.5 x 10^7; log Pow: 7.7
Compound 2: Pow: 4.8 x 10^8; log Pow: 8.7
Compound 3: Pow: 2.8 x 10^9; log Pow: 9.5
Compound 4: Pow: 1.6 x 10^11; log Pow: 11.2
Compound 5: Pow: 2.3 x 10^12; log Pow: 12.4
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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