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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: study was documentation insufficient

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1984

Materials and methods

Principles of method if other than guideline:
Male mice of ddY strain weighing about 25g were used throughout the experiment. The oral LD50 values for test were measured according to Weil (1952) using four animals per dose level and four different doses.
GLP compliance:
not specified
Test type:
other: acc. to Weil 1952

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methylbutyronitrile
EC Number:
242-687-1
EC Name:
2-methylbutyronitrile
Cas Number:
18936-17-9
Molecular formula:
C5H9N
IUPAC Name:
2-Methylbutyronitrile

Test animals

Species:
mouse
Strain:
other: ddY
Sex:
male
Details on test animals or test system and environmental conditions:
weighing 25 g

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
No. of animals per sex per dose:
4 animals per dose and 4 doses
Control animals:
not specified
Details on study design:
Weil, 1952
Statistics:
Hansch's model (Hansch and Fujita (1969) J Am Chem Soc 86: 1616-1626

Results and discussion

Preliminary study:
LD50 0,2153-0,3818
Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
0.287 other: mmol/kg
Based on:
not specified
95% CL:
0.153 - 0.382

Applicant's summary and conclusion

Interpretation of results:
toxic
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
oral toxicity with LD50 0,2867 nmol/kg
lowest LD50 of 21 nitriles in mice tested in a comparative study
Executive summary:

The acute oral toxicity was determined in male mice. LD50 0,2867 mmol/kg