Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1974

Materials and methods

Study type:
study with volunteers
Principles of method if other than guideline:
A maximization test (Kligman, 1966; Kligman & Epstein, 1975) was carried out on 25 healthy male and female volunteers. Application was under occlusion to the same site on the forearms of all subjects for five alternate-day 48 hour periods. Patch test sites were pretreated for 24 hours with 5% aqueous sodium lauryl sulfate under occlusion. Following a ten day rest period, a challenge patch was applied to a fresh site for 48 hours under occlusion. Reactions to challege were read at patch removal and 24 hours after patch removal.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Neral
IUPAC Name:
Neral

Method

Route of administration:
dermal

Results and discussion

Results of examinations:
Vehicle was petrolatum
5 % sensitization effects
17/25 positive.

Applicant's summary and conclusion

Conclusions:
5 % sensitization effects
17/25 positive.