Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 223-622-6 | CAS number: 3982-91-0
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No GLP and no guideline study. The study has methodological deficiencies and is insufficient reported.
Data source
Reference
- Reference Type:
- publication
- Title:
- Short-term test systems to assess thiophosphoryl chloride standards
- Author:
- Colosi-Esca D, Snca Z, Barbarino F, Surcel D, Papilian VV
- Year:
- 1 984
- Bibliographic source:
- J. Appl. Toxicol. 4, 230-235
Materials and methods
- Principles of method if other than guideline:
- In a 30 day subchronic feeding study, young male and female Wistar rats were dosed at 5 % of the LD50 value (resp 37.5 mg/kg bw) as milk emulsion. Cytogenetic effects in bone marrow were analysed using the method of Ford and Woollam (1963).
- GLP compliance:
- not specified
- Type of assay:
- chromosome aberration assay
Test material
- Reference substance name:
- Thiophosphoryl trichloride
- EC Number:
- 223-622-6
- EC Name:
- Thiophosphoryl trichloride
- Cas Number:
- 3982-91-0
- Molecular formula:
- Cl3PS
- IUPAC Name:
- phosphorothioyl trichloride
- Details on test material:
- no further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no further data
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- Milk emulsion
- Details on exposure:
- In a 30 day subchronic feeding study, young male and female Wistar rats were dosed at 5 % of the LD50 value (resp 37.5 mg/kg bw) as milk emulsion. Cytogenetic effects in bone marrow were analysed using the method of Ford and Woollam (1963).
- Duration of treatment / exposure:
- 30 day feeding study
- Frequency of treatment:
- daily
- Post exposure period:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
37.5 mg/kg bw/day
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- no data
Examinations
- Tissues and cell types examined:
- Bone marrow
- Details of tissue and slide preparation:
- no details given
- Evaluation criteria:
- no information given
- Statistics:
- no data
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- valid
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- There were no significant differences in the incidence of abnormalities in the test group compared with the controls.
Any other information on results incl. tables
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
- Executive summary:
In a 30 day subchronic feeding study, young male and female Wistar rats were dosed at 5 % of the LD50 value (resp 37.5 mg/kg bw) as milk emulsion. Cytogenetic effects in bone marrow were analysed using the method of Ford and Woollam (1963). There were no significant differences in the incidence of abnormalities in the test group compared with the controls (Colosi-Esca 1984).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
