Registration Dossier
Registration Dossier
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EC number: 223-622-6 | CAS number: 3982-91-0
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Special investigation
Data source
Reference
- Reference Type:
- publication
- Title:
- Major intermediates in organophosphate synthesis (PCl3, POCl3, PSCl3 and their diethyl esters) are anticholinesterase agents directly or on activation
- Author:
- Segall Y, Quistad GB, Sparks SE, Casida JE
- Year:
- 2 003
- Bibliographic source:
- Chem Res Toxicol 16, 350-356
Materials and methods
- Type of study / information:
- Effects on enzymes
Test guideline
- Qualifier:
- no guideline followed
Test material
- Reference substance name:
- Thiophosphoryl trichloride
- EC Number:
- 223-622-6
- EC Name:
- Thiophosphoryl trichloride
- Cas Number:
- 3982-91-0
- Molecular formula:
- Cl3PS
- IUPAC Name:
- phosphorothioyl trichloride
Constituent 1
Results and discussion
Any other information on results incl. tables
Thiophosphoryl trichloride (PSCl3) is less active in inhibition of acetylcholin esterase and butyrylcholine esterase than phosphorus trichloride (PCl3) and phosphoryl trichloride (POCl3).
Applicant's summary and conclusion
- Executive summary:
Thiophosphoryl trichloride (PSCl3) is less active in inhibition of acetylcholin esterase and butyrylcholine esterase than phosphorus trichloride (PCl3) and phosphoryl trichloride (POCl3).
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