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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: well described study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Draize
Principles of method if other than guideline:
Three male and three female New Zealand White rabbits with 0.5 ml of n-butyl acetate applied to the clipped, intact skin under a gauze patch and loosely covered with impervious sheeting. The animals were restrained for the 4-hour exposure period. Excess liquid was removed at the end of the exposure period. Skin reactions were scored by the Draize method at one hour and 1, 2, 3, 7, 10 and 14 days post-exposure.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N-butyl acetate
EC Number:
204-658-1
EC Name:
N-butyl acetate
Cas Number:
123-86-4
Molecular formula:
C6H12O2
IUPAC Name:
butyl acetate
Details on test material:
n-butyl acetate. Analytical data available but not included in available records. Commercial Sample used in testing (99.6 % Purity).

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
occlusive
Preparation of test site:
clipped
Amount / concentration applied:
0,5 ml
Observation period:
Skin reactions were scored by the Draize method at one hour and 1, 2, 3, 7, 10 and 14 days post-exposure.
Number of animals:
Three male and three female

Results and discussion

In vivo

Results
Irritation parameter:
other: Mean Draize
Basis:
mean
Score:
0
Reversibility:
fully reversible

Any other information on results incl. tables

The four hour exposure did not cause erythema, edema, or any other signs of skin irritation. Mean Draize scores for erythema , eschar, and edema were 0.0 for all animals tested at all post-exposure intervals.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
not irritating