Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
2002
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Cited experiments were summarized in the European Chemicals Bureau Methyloxirane (Propylene Oxide) Risk Assessment Report. The original studies were not reviewed.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2002

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
propylene oxide
IUPAC Name:
propylene oxide
Constituent 2
Reference substance name:
Methyloxirane
EC Number:
200-879-2
EC Name:
Methyloxirane
Cas Number:
75-56-9
IUPAC Name:
2-methyloxirane

Results and discussion

Applicant's summary and conclusion

Conclusions:
A single oral dose in the rat, by gavage, of 1,000 mg/kg resulted in 100% mortality, while no deaths occurred at 300 mg/kg. This suggests that the
LD50 is below 1,000 mg/kg and the slope of the dose-effect relationship is quite steep.

A rat LD50 of 1.14 mL/kg (950 mg/kg) has also been reported. In another study, the oral LD50 values for the rat, mouse and guinea pig were
reported to be 520 mg/kg, 630 mg/kg and 660 mg/kg, respectively. A guinea pig LD50 of 690 mg/kg has also been reported.