Registration Dossier

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to current guideline requirements and scientifically valid with acceptable restrictions.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1991

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 406 (Skin Sensitisation)
Deviations:
yes
Remarks:
No. of animals, vehicle, score not specified
Principles of method if other than guideline:
footpad drop on
GLP compliance:
not specified
Type of study:
other: footpad drop on

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chlorobenzaldehyde
EC Number:
201-956-3
EC Name:
2-chlorobenzaldehyde
Cas Number:
89-98-5
Molecular formula:
C7H5ClO
IUPAC Name:
2-chlorobenzaldehyde
Details on test material:
- Name of test material (as cited in study report): o-chlorobenzaldehyde
- Physical state: colorless to pale yellow liquid

In vivo test system

Test animals

Species:
guinea pig
Details on test animals and environmental conditions:
Source: Mary Nobel

Study design: in vivo (non-LLNA)

Induction
Route:
intradermal
No. of animals per dose:
5 animals
Details on study design:
Dosing:
Group No.1: drop on - 1% in guinea pig fat
Group No.2: footpad injection - 1% in rabbit blood; drop on - 1% in guinea pig fat
Group No.3: footpad injection - plain rabbit blood; drop on - 1% in guinea pig fat
Positive control substance(s):
not specified

Results and discussion

Any other information on results incl. tables

Initial score (not further defined) was 1.2, final score after 24 and 48 hrs was between 1.4 and 1.8. One out of five guinea pigs was sensitized by an intradermal application of 2-chlorobenzaldehyde.

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Regarding the results of the study, the test substance 2-chlorobenzaldeyde is considered to have moderate sensitizing activity.