Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to current guideline requirements and scientifically valid with acceptable restrictions.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1991

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
yes
Remarks:
no grading of skin reaction, test dose leading to effects described not specified
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chlorobenzaldehyde
EC Number:
201-956-3
EC Name:
2-chlorobenzaldehyde
Cas Number:
89-98-5
Molecular formula:
C7H5ClO
IUPAC Name:
2-chlorobenzaldehyde
Details on test material:
- Name of test material (as cited in study report): o-chlorobenzaldehyde
- Physical state: colorless to pale yellow liquid

Test animals

Species:
guinea pig
Strain:
not specified
Details on test animals or test system and environmental conditions:
source: Mary Nobel

Test system

Type of coverage:
other: impervious cuff
Controls:
not specified
Amount / concentration applied:
5-20 g/kg
Observation period:
14 days
Number of animals:
3

Results and discussion

Any other information on results incl. tables

Irritation/corrosion results:

after 24 hr.: Slight to severe erythema with scattered necrosis and gross oedema.

after 1 wk.: Slight edema, slight to moderate erythema, scattered thin to heavy eschars and some scarring.

after 2 wk.: Some scattered eschars or scarring over patch and complete alopecia.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Regarding the results of the study, the test substance 2-chlorobenzaldehyde is considered to be corrosive.