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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to current guideline requirements and scientifically valid with acceptable restrictions.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1991

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
number of animals per dose group and number of dose groups not mentioned, no GLP study, number of dead animals-no data
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chlorobenzaldehyde
EC Number:
201-956-3
EC Name:
2-chlorobenzaldehyde
Cas Number:
89-98-5
Molecular formula:
C7H5ClO
IUPAC Name:
2-chlorobenzaldehyde
Details on test material:
- Name of test material (as cited in study report): o-chlorobenzaldehyde
- Physical state: colorless to pale yellow liquid

Test animals

Species:
mouse
Details on test animals or test system and environmental conditions:
20 rats and 20 mice were exposed to the test substance by oral route

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Doses:
200-3200 mg/kg
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 1 900 mg/kg bw
Based on:
test mat.
Remarks on result:
other: mouse LD50
Mortality:
time of death: 4-7 days post dose
Clinical signs:
Normal to very weak tremor, diarrhea.

Applicant's summary and conclusion

Interpretation of results:
sligthly toxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Regarding the results of the study, the test substance o-chlorobenzaldehyde is considered to be slightly toxic (Acute toxicity oral Cat.4 accordig to GHS and GHS UN).