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Administrative data

Description of key information

acute toxicity oral:
rats: LD50 ca.2160 mg/kg bw
mice: LD50 ca. 1900 mg/kg bw

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
1 900 mg/kg bw
Quality of whole database:
The whole database is conclusive and of high quality.

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Acute oral toxicity was tested in a study, where 20 rats and 20 mice received a single oral application of 200 -3200 mg/kg bw of the test substance 2-chlorobenzaldehyde. After dosing, observations were recorded for 14 days. Because deaths as well as clinical signs of toxicity were observed in both species, the LD50 for acute oral toxicity was estimated as 2160 mg/kg bw for rats and 1900 mg/kg bw for mice.


Justification for selection of acute toxicity – oral endpoint
Comparable to current guideline requirements and scientifically valid with acceptable restrictions.

Justification for classification or non-classification

Due to the effect levels obtained in the acute oral toxicity studie, a classification into Cat. 4 according to EU and GHS criteria is required.

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