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EC number: 201-956-3
CAS number: 89-98-5
Cutaneously administered 14C-2-chlorobenzaldehyde (75 µI/kg) was well
absorbed by the skin of rats as indicated by plasma radioactivity levels
and the high total recovery of radioactivity. The slow increase in
plasma-radioactivity was shown in all cutaneous experiments and the peak
plasma concentrations of 4000-6000 dpm/g were reached 10 -15 h post
dosing. Thereafter the plasma-radioactivity declined slowly with a 14C
half-life ranging between 20 and 40 h.
The major portion of radioactivity was excreted in the urine. Small
amounts were found in the faeces and in the exhaled air. The cutaneously
administered radioactivity was mainly recovered from urine, faeces and
glasscup over a 3-day period. Urinary excretion of the radioactivity was
found about 45% within the first 24 h post dosing: About 15% of the 75
µl/kg dose of 14C-2-chlorobenzaldehyde was found in the glasscup and on
the skin. The exhalation of 14C02 over a period of 72 h was minimal,
approximately 1% of the dose.
The principal metabolite in rat urine was 2-chlorohippuric acid . The
radioactivity derived from 14C-2-chlorobenzyl alcohol was mostly
excreted in the second-day urine of the cutaneously treated rats. About
15% of the total urinary radioactivity was eliminated as 2-chlorobenzyl
alcohol and 2-chlorobenzoic acid into urine within 72 h (cutaneous).
No radioactivity was retained in the red blood cells after
administration of 14C-2-chlorobenzaldehyde .
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