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EC number: 235-869-7 | CAS number: 13014-24-9
For the calculation, the Draize scores approx 24, 48 and 72 hours after application were used.
A study for irritant/corrosive potential on the rabbit's eye was conducted with 3,4 -Dichlorbenzotrichlorid in accordance with OECD Guideline for Testing of Chemical n. 405. In respect to the OECD Interpretation Guides results were interpreted in conjunction with the nature, intensity, and reversibility of the observed responses.
After an acclimation period of at least 14 days before the test start, an application volume of 100 µL test substance was instilled into the conjunctival sac of one ye of each of the three rabbits after gently pulling the lower lid away from the eyeball. the lids were gently held together for about one second. The other eye remained untreated and served as control. The treated eye was washed out with physiological NaCl solution 24 hours after instillation of the test substance.The examinations of cornea iris and aqueous humour were facilitated by use of optical instruments (e.g. hand slit-lamp). To define epithelial damage, one drop of a 1% fluorescein solution was applied to the corneal surface 24 hrs after application of the test substance.. the eye was then rinsed with physiological NaCl solution in order to remove excess and nonabsorbed fluorescein. Evaluation was performed by means of UV (area) and diffuse white illumination (intensity) according to McDonald and Shadduck, modified.
The test substance resulted to be not irritant to the rabbit's eye.
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