Registration Dossier
Registration Dossier
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EC number: 403-920-4 | CAS number: 107551-67-7 G 19-675 ZP
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From Mar. 10, 1989 to Mar. 30, 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented, according to accepted guideline, with GLP-like Quality Assurance
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EEC directive 84/449 C.10
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-(3-tert-butyl-4-hydroxyphenyl)propionic acid
- EC Number:
- 403-920-4
- EC Name:
- 3-(3-tert-butyl-4-hydroxyphenyl)propionic acid
- Cas Number:
- 107551-67-7
- Molecular formula:
- C13H18O3
- IUPAC Name:
- 3-(3-tert-butyl-4-hydroxyphenyl)propanoic acid
- Details on test material:
- - Lot/batch No.: EN.116905.72
Constituent 1
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent/transformation products: 2.4 hours and 5 days
- Buffers:
- pH 4:
standard acetate buffer ( 0.1 mole/1 acetic acid + 0.1 mole/1 sodium acetate ) + 15 ml acetic acid per liter.
pH 7:
0.041 mole di-sodium-hydrogenphosphate + 0.028 mole potassium-dihydrogenphosphate per liter.
pH 9:
0.043 mole di-sodium-tetraborate + 0.017 mole potassium-dihydrogenphosphate per liter. - Details on test conditions:
- Report states according to EEC guideline 84/449 C.10
Duration of testopen allclose all
- Duration:
- 2.4 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 0.71 g/L
- Duration:
- 2.4 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 0.71 g/L
- Duration:
- 2.4 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 0.71 g/L
- Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 0.71 g/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 0.71 g/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 0.71 g/L
- Number of replicates:
- 2 replicates per treatment condition
- Positive controls:
- not specified
- Negative controls:
- not specified
- Statistical methods:
- none reported
Results and discussion
- Preliminary study:
- The test substance is stable at pH 4, 7, and 9 (less than 10% decomposition after 5 days)
- Transformation products:
- not measured
- Details on hydrolysis and appearance of transformation product(s):
- not reported
- Details on results:
- The test substance is stable at pH 4, 7, and 9 (less than 10% decomposition after 5 days)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
