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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
August 05 - 26, 1998
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1998
Report date:
1998

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Qualifier:
according to guideline
Guideline:
EU Method B.3 (Acute Toxicity (Dermal))
GLP compliance:
yes
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
α,α,α,β,β,β-hexafluoro-m-xylene
EC Number:
206-939-4
EC Name:
α,α,α,β,β,β-hexafluoro-m-xylene
Cas Number:
402-31-3
Molecular formula:
C8H4F6
IUPAC Name:
1,3-bis(trifluoromethyl)benzene
Test material form:
other: liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
corn oil
Duration of exposure:
14 days
Doses:
The test article was diluted in vehicle (corn oil) at a concentration of 0.5 g/mL and administered at a volume of 4 ml/kg.
No. of animals per sex per dose:
5 male and 5 female rats

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

No deaths occurred during the study.

Crusts were observed on the application site in one male animal from test day 7 to 12. No clinical signs were observed in all other male and female animals during the observation period. Two female animals showed a slight loss of body weight during the first week of observation. They recovered during the second week of observation. The body weight of all other animals was within the range comonly recorded for animals of this strain and age.

No macroscopic findings were observed at necropsy.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The median lethal dose of 1,3 Hexafluoroxylene after single dermal administration to rats of both sexes, observed over a period of 14 days, could not be estimated as no death occurred. LD50 is greater than 2000 mg/kg body weight.

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