Registration Dossier
Registration Dossier
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EC number: 700-202-5 | CAS number: 765-63-9
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to OECD 105 and EEC method A6 and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- 2,2,3,3-tetrafluorooxetane
- EC Number:
- 700-202-5
- Cas Number:
- 765-63-9
- Molecular formula:
- C3H2F4O
- IUPAC Name:
- 2,2,3,3-tetrafluorooxetane
- Details on test material:
- - Name: TFO
- Chemical name: 2,2,3,3-Tetrafluorooxetane
- Appearance: Transparent liquid
- Storage conditions: Room temperature
- Lot number: TFOS285001
- Purity: 99%
- Expiry date: 30 April 2010
- Date received: 16 October 2008
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 24 g/L
- Temp.:
- 20 °C
- pH:
- 0.1 - 0.6
- Details on results:
- The detector calibration was found to be linear over the range 0 to 1600 mg/l of standard solutions in acetone with a regression coefficient of 0.9991.
The water solubility of TFO was 23.9 ± 1.9 g/l. The low pH of the samples was considered to be due to the presence of acidic degradates. Table 3 presents the primary data for this test.
There were no interfering peaks in blank control solutions, whilst a mean recovery of approximately 90% of TFO from fortified control samples was achieved and deemed to be acceptable.
Any other information on results incl. tables
The very low pH of the test solutions at the end of the test period (pH 0.1 to 0.6) suggests that the substance was hydrolysed during testing. This is consistent with the observation in the biodegradation test that "The test item was hydrolyzed completely and converted into 2,2-difluoro-3-hydroxy-propionic acid and fluoride ion under the test condition of the study". This also explains why the log Pow is so high (log Pow = 5.3) for an apparently water soluble substance.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): very soluble (> 10000 mg/L)
TFO was found to have a water solubility of 24 g/l at 20°C.
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