Registration Dossier
Registration Dossier
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EC number: 255-280-9 | CAS number: 41253-21-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD 405). No GLP study. For further information please refer to ECHA disseminated dossier.
Data source
Reference
- Reference Type:
- other: ECHA disseminated dossier
- Title:
- No information
- Year:
- 1 992
- Bibliographic source:
- ECHA disseminated dossier CAS 41253-21-8 query date 2014-11-20
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- 1H-1,2,4-triazole, sodium salt
- EC Number:
- 255-280-9
- EC Name:
- 1H-1,2,4-triazole, sodium salt
- Cas Number:
- 41253-21-8
- Molecular formula:
- C2H3N3.Na
- IUPAC Name:
- sodium 1,2,4-triazol-1-ide
Constituent 1
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 h
- Score:
- ca. 3.7
- Max. score:
- 4
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 h
- Score:
- 3
- Max. score:
- 3
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 h
- Score:
- 2
- Max. score:
- 2
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 h
- Score:
- 4
- Max. score:
- 4
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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