Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 255-280-9 | CAS number: 41253-21-8
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
Adsorption to solid soil phase is not expected.
Key value for chemical safety assessment
- Koc at 20 °C:
- 4.996
Additional information
QSAR-disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of 1H-1,2,4-triazole, sodium salt (Q)SAR results were used for Estimation of Soil Adsorption Coefficient . The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, further experimental studies on Estimation of Soil Adsorption Coefficient are not provided. The test item would be very mobile in soil with a very low adsorption onto sediments.
According to Annex IX, section 9.3.1 of REGULATION (EC) No 1907/2006, the study does not need to be conducted if, based on the physicochemical properties, the substance can be expected to have a low potential for adsorption (e.g. the substance has a low octanol water partition coefficient). Due to its log Kow of - 0.70, the condition is fulfilled and adsorption/desorption study is not scientifically justified.
Using KOCWIN v2.00 the Koc was calculated using the MCI method and the log Kow mehtod.
Using the MCI method the log Koc was calculated to be 0.699 at 25 °C. The substance is not within the applicability domain of the model. The molecular weight is within range of training set, but not within validation set. Thus the estimation was regarded to be less accurate.
Using the log Kow method the log Koc was calculated to be 0.6108 at 25 °C. The substance is not within the applicability domain of the model. The molecular weight is within range of training set, but not within validation set. Thus the estimation was regarded to be less accurate.
+A log Koc of 0.699 was chosen as key value for chemical safety assessment as it was regarded as worst case assumption.
[LogKoc: 0.699]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
